Stephan, JBJS Rev 2016 - Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm

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Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm

Stephan, Mulcahey, et al.·JBJS Rev·2016·96 citations·Review article

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Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved. Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules. The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method. Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition. Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.

Copyright remains with the authors and publisher.

Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm.

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Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm

Stephan, Mulcahey, et al.·JBJS Rev·2016·96 citations·Review article

|

Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved. Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules. The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method. Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition. Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.

Copyright remains with the authors and publisher.

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