This 2004 NEJM review by Roodman examines the molecular and cellular mechanisms driving bone metastasis across cancer types. It asks why bone is such a preferred metastatic site and how osteolytic versus osteoblastic lesion patterns arise from dysregulated tumor-bone crosstalk. It synthesizes the evidence on RANKL/OPG signaling, the PTHrP-driven vicious circle in breast cancer, and the unique biology of myeloma bone disease.
This 2004 NEJM review by Roodman examines the molecular and cellular mechanisms driving bone metastasis across cancer types. It asks why bone is such a preferred metastatic site and how osteolytic versus osteoblastic lesion patterns arise from dysregulated tumor-bone crosstalk. It synthesizes the evidence on RANKL/OPG signaling, the PTHrP-driven vicious circle in breast cancer, and the unique biology of myeloma bone disease.