Caplan proposed that bone and cartilage arise from a common mesenchymal stem cell (MSC) whose lineage progression is controlled by intrinsic genomic and extrinsic local factors. Review synthesizing embryonic and adult lineage studies, including ceramic implant, culture-density and nude mouse implantation experiments with marrow-derived MSCs.
Caplan proposed that bone and cartilage arise from a common mesenchymal stem cell (MSC) whose lineage progression is controlled by intrinsic genomic and extrinsic local factors. Review synthesizing embryonic and adult lineage studies, including ceramic implant, culture-density and nude mouse implantation experiments with marrow-derived MSCs.