Comprehensive narrative review synthesizing in vitro and in vivo evidence on how scaffold porosity and pore size govern bone formation and scaffold mechanical integrity across ceramics, metals, natural polymers, synthetic polymers, and composites.
When evaluating bone graft substitutes or scaffold materials, understand that pore size directly affects the type of bone formation - smaller pores may lead to cartilage formation first, while larger pores promote direct bone formation with better vascularization.
Comprehensive narrative review synthesizing in vitro and in vivo evidence on how scaffold porosity and pore size govern bone formation and scaffold mechanical integrity across ceramics, metals, natural polymers, synthetic polymers, and composites.
When evaluating bone graft substitutes or scaffold materials, understand that pore size directly affects the type of bone formation - smaller pores may lead to cartilage formation first, while larger pores promote direct bone formation with better vascularization.