Mundy's 2002 review maps the molecular mechanisms by which breast, lung, and prostate cancers colonize and destroy bone. It identifies PTHrP and endothelin-1 as the key mediators of osteolytic and osteoblastic metastasis, respectively. The review establishes the vicious cycle framework and its direct therapeutic implications for bisphosphonate and targeted antibody use.
Mundy's 2002 review maps the molecular mechanisms by which breast, lung, and prostate cancers colonize and destroy bone. It identifies PTHrP and endothelin-1 as the key mediators of osteolytic and osteoblastic metastasis, respectively. The review establishes the vicious cycle framework and its direct therapeutic implications for bisphosphonate and targeted antibody use.