Kong et al. generated opgl gene knockout mice to test whether OPGL/RANKL — a TNF-family molecule expressed by osteoblasts and T cells — is truly essential for osteoclast formation and bone remodeling in vivo, and whether it has additional roles in the immune system beyond what cell culture suggested.
Kong et al. generated opgl gene knockout mice to test whether OPGL/RANKL — a TNF-family molecule expressed by osteoblasts and T cells — is truly essential for osteoclast formation and bone remodeling in vivo, and whether it has additional roles in the immune system beyond what cell culture suggested.