This 2012 narrative review by Loeser et al. synthesizes OA pathophysiology across all joint tissues: cartilage, subchondral bone, synovium, menisci, and ligaments. It argues that OA is not passive wear-and-tear but an active, inflammation-driven remodeling process affecting the entire joint as an organ. The review catalogs molecular targets and therapeutic rationale, establishing the 'joint failure' framework that now underpins OA research and clinical guidelines.
This 2012 narrative review by Loeser et al. synthesizes OA pathophysiology across all joint tissues: cartilage, subchondral bone, synovium, menisci, and ligaments. It argues that OA is not passive wear-and-tear but an active, inflammation-driven remodeling process affecting the entire joint as an organ. The review catalogs molecular targets and therapeutic rationale, establishing the 'joint failure' framework that now underpins OA research and clinical guidelines.