Prospective Rotterdam Study cohort of 7,806 adults ≥55 years followed 6.8 years to measure incidence of all non-vertebral fractures by site and gender, quantify the BMD–fracture hazard relationship in both sexes, and test how well the WHO T-score ≤-2.5 threshold identifies patients who will actually fracture.
When you see a patient with a non-traumatic fracture who has a T-score above -2.5, don't be falsely reassured — this study shows that the majority of fractures occur in osteopenic or normal-BMD individuals.
Always supplement BMD with clinical risk factors (age, prior fracture, medication use, comorbidities) when assessing fracture risk, and consider FRAX-based absolute risk estimation rather than treating T-score as a binary treatment threshold.
Prospective Rotterdam Study cohort of 7,806 adults ≥55 years followed 6.8 years to measure incidence of all non-vertebral fractures by site and gender, quantify the BMD–fracture hazard relationship in both sexes, and test how well the WHO T-score ≤-2.5 threshold identifies patients who will actually fracture.
When you see a patient with a non-traumatic fracture who has a T-score above -2.5, don't be falsely reassured — this study shows that the majority of fractures occur in osteopenic or normal-BMD individuals.
Always supplement BMD with clinical risk factors (age, prior fracture, medication use, comorbidities) when assessing fracture risk, and consider FRAX-based absolute risk estimation rather than treating T-score as a binary treatment threshold.