The VANCO Study is a phase III multicenter RCT conducted at 34 US trauma centers (METRC network) testing whether 1000 mg of intrawound vancomycin powder reduces deep surgical site infections after plate fixation of high-risk tibial plateau and pilon fractures. This protocol paper describes the design, eligibility criteria, intervention, and statistical plan for 1000 enrolled patients.
This trial established the evidence base for using local vancomycin powder in high-risk tibial fracture fixation.
The 1000 mg maximum dosing and timing protocol (placement immediately before wound closure) became standard practice at many trauma centers for tibial plateau and pilon fractures with elevated infection risk.
The VANCO Study is a phase III multicenter RCT conducted at 34 US trauma centers (METRC network) testing whether 1000 mg of intrawound vancomycin powder reduces deep surgical site infections after plate fixation of high-risk tibial plateau and pilon fractures. This protocol paper describes the design, eligibility criteria, intervention, and statistical plan for 1000 enrolled patients.
This trial established the evidence base for using local vancomycin powder in high-risk tibial fracture fixation.
The 1000 mg maximum dosing and timing protocol (placement immediately before wound closure) became standard practice at many trauma centers for tibial plateau and pilon fractures with elevated infection risk.