Background
This study aims to quantitatively summarize risk factors associated with heterotopic ossification after total hip arthroplasty.
Methods
- The computerized and additional manual searches were performed in Medline, Embase, CNKI, and Cochrane central database (all through March 2014) for potential studies.
- Studies eligible had to meet the quality assessment criteria by Newcastle-Ottawa Scale and to evaluate the risk factors for heterotopic ossification after total hip arthroplasty.
- Two reviewers independently extracted the relevant data and any disagreement was solved by consensus.
- Stata11.0 was used to perform all the statistical analyses.
Results
- 14 studies involving 6468 cases with total hip arthroplasty and 1939 heterotopic ossification (HOs) (30.0 %) were eligible and included in this meta-analysis.
- Our meta-analysis identified the significant increased risk factors for HO were male gender [odds ratio (OR) 2.11; 95 % confidence interval (CI) 1.80-2.48)], cemented implant (OR 1.48; 95 % CI 1.00-2.17), bilateral operations (OR 1.74; 95 % CI 1.24-2.45), ankylosing spondylitis (OR 1.90; 95 % CI 1.07-3.37) and ankylosed hip (OR 9.85; 95 % CI 2.61-37.24).
- Rheumatoid arthritis was protective for the development of HO (OR 0.51; 95 % CI 0.33-0.80).
- The other variables including age, use of NSAIDs, femoral neck fracture, previous hip fracture, hypertrophic osteoarthritis and osteophytes were identified not as the risk factors for development of HO (P > 0.05).
Conclusions
Patients involved with the above-mentioned medical conditions should be carefully paid close attention by surgeons to reduce HO after total hip arthroplasty.
Level of evidence: Level II, meta-analysis. Copyright remains with the authors and publisher.