Wynne-Davies studied 635 patients with congenital foot deformities (talipes equinovarus, talipes calcaneo-valgus, metatarsus varus) treated in Devonshire from 1926–1961, using family histories, sibling data, and twin studies to characterize the inheritance pattern and identify associated anomalies.
When a family asks about recurrence after one child is born with clubfoot, quote these numbers: ~1 in 35 for the next sibling (vs. 1 in 800 in the general population), and remind them that if the index patient is female, her brothers face the highest relative risk.
A detailed family history for joint laxity and connective tissue features is warranted at the initial evaluation.
Wynne-Davies studied 635 patients with congenital foot deformities (talipes equinovarus, talipes calcaneo-valgus, metatarsus varus) treated in Devonshire from 1926–1961, using family histories, sibling data, and twin studies to characterize the inheritance pattern and identify associated anomalies.
When a family asks about recurrence after one child is born with clubfoot, quote these numbers: ~1 in 35 for the next sibling (vs. 1 in 800 in the general population), and remind them that if the index patient is female, her brothers face the highest relative risk.
A detailed family history for joint laxity and connective tissue features is warranted at the initial evaluation.