This 2007 meta-analysis by Prodromos et al. pooled 20 published allograft ACL reconstruction series and compared their arthrometric stability outcomes to a previously published autograft dataset using identical inclusion criteria — asking whether allografts produce equivalent objective stability to autografts at minimum two-year follow-up.
When counseling patients on graft choice for primary ACL reconstruction, this meta-analysis provides level IV evidence that autografts yield significantly better objective stability and roughly one-third the failure rate of allografts — reserve allografts for multi-ligament injuries or revision cases where autograft tissue is insufficient, and avoid irradiated allograft preparations given their substantially higher failure rates.
This 2007 meta-analysis by Prodromos et al. pooled 20 published allograft ACL reconstruction series and compared their arthrometric stability outcomes to a previously published autograft dataset using identical inclusion criteria — asking whether allografts produce equivalent objective stability to autografts at minimum two-year follow-up.
When counseling patients on graft choice for primary ACL reconstruction, this meta-analysis provides level IV evidence that autografts yield significantly better objective stability and roughly one-third the failure rate of allografts — reserve allografts for multi-ligament injuries or revision cases where autograft tissue is insufficient, and avoid irradiated allograft preparations given their substantially higher failure rates.