This 2002 JBJS Current Concepts Review by Lieberman, Daluiski, and Einhorn examines the biology and clinical potential of five growth factors — BMP, TGF-β, FGF, PDGF, and IGF — in bone repair. It synthesizes preclinical animal data and early human trials to evaluate which factors are ready for clinical translation and what delivery challenges remain.
This 2002 JBJS Current Concepts Review by Lieberman, Daluiski, and Einhorn examines the biology and clinical potential of five growth factors — BMP, TGF-β, FGF, PDGF, and IGF — in bone repair. It synthesizes preclinical animal data and early human trials to evaluate which factors are ready for clinical translation and what delivery challenges remain.