Prospective diagnostic study testing 16 synovial fluid biomarkers for PJI in 95 revision hip/knee arthroplasty patients — including those with systemic inflammatory disease and active antibiotic treatment — using the MSIS definition as the gold standard (29 infected, 66 aseptic).
This study suggests that synovial fluid biomarkers, particularly α-defensin, may offer a simpler and equally accurate alternative to the complex MSIS criteria for PJI diagnosis, even in challenging cases where traditional markers might be less reliable.
Prospective diagnostic study testing 16 synovial fluid biomarkers for PJI in 95 revision hip/knee arthroplasty patients — including those with systemic inflammatory disease and active antibiotic treatment — using the MSIS definition as the gold standard (29 infected, 66 aseptic).
This study suggests that synovial fluid biomarkers, particularly α-defensin, may offer a simpler and equally accurate alternative to the complex MSIS criteria for PJI diagnosis, even in challenging cases where traditional markers might be less reliable.