This 1967 Mayo Clinic retrospective series characterizes 600 pathologically confirmed osteosarcomas treated between 1909 and 1964. It asks who gets this tumor, where it occurs, and what fraction of patients survive — all before the advent of chemotherapy. It is the definitive natural-history description of osteosarcoma in the surgical-only era.
This 1967 Mayo Clinic retrospective series characterizes 600 pathologically confirmed osteosarcomas treated between 1909 and 1964. It asks who gets this tumor, where it occurs, and what fraction of patients survive — all before the advent of chemotherapy. It is the definitive natural-history description of osteosarcoma in the surgical-only era.