Charnley, J Bone Joint Surg Br 1970 - The Reaction of Bone to Self-Curing Acrylic Cement. A Long-Term Histological Study in Man

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The Reaction of Bone to Self-Curing Acrylic Cement. A Long-Term Histological Study in Man

Charnley·J Bone Joint Surg Br·1970·263 citations·Anatomic study

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1. A general picture of the histological state of the bone-cement junction, up to 7 years after implantation, is presented as a result of the study of 23 human specimens. 2. The transmission of load from cement to bone occurs at isolated points through the medium of newly formed fibrocartilage. 3. It is clear that this fibrocartilage has been produced in response to mechanical pressure on fibrous tissue which has undergone compression between cement and underlying bone. 4. Direct contact exists between the surface of the cement and the newly formed fibrocartilage at these sites of load transmission. 5. Load-bearing fibrocartilage frequently shows areas of ossification extending into it from the underlying bone. 6. Where soft tissues in contact with cement are too thick or too delicate for load transmission a thin layer of giant-cell cytoplasm coats the cement surface. 7. No collections of giant cells to form granulomatous or caseating areas have been seen. 8. Fat storage, indicating the absence of chemical irritation, can occur within 10 microns of the cement surface.

Copyright remains with the authors and publisher.

The Reaction of Bone to Self-Curing Acrylic Cement. A Long-Term Histological Study in Man.

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The Reaction of Bone to Self-Curing Acrylic Cement. A Long-Term Histological Study in Man

Charnley·J Bone Joint Surg Br·1970·263 citations·Anatomic study

|

1. A general picture of the histological state of the bone-cement junction, up to 7 years after implantation, is presented as a result of the study of 23 human specimens. 2. The transmission of load from cement to bone occurs at isolated points through the medium of newly formed fibrocartilage. 3. It is clear that this fibrocartilage has been produced in response to mechanical pressure on fibrous tissue which has undergone compression between cement and underlying bone. 4. Direct contact exists between the surface of the cement and the newly formed fibrocartilage at these sites of load transmission. 5. Load-bearing fibrocartilage frequently shows areas of ossification extending into it from the underlying bone. 6. Where soft tissues in contact with cement are too thick or too delicate for load transmission a thin layer of giant-cell cytoplasm coats the cement surface. 7. No collections of giant cells to form granulomatous or caseating areas have been seen. 8. Fat storage, indicating the absence of chemical irritation, can occur within 10 microns of the cement surface.

Copyright remains with the authors and publisher.

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