This retrospective series from the Istituto Rizzoli reviews 280 patients with giant-cell tumor of bone followed for up to 44 years, asking which factors — radiographic grade, surgical margin, or adjuvant therapy — determine local recurrence, malignant transformation, and metastasis.
Surgical approach is the primary determinant of recurrence risk in GCT - wide excision eliminates recurrence but intralesional curettage carries significant risk. Most recurrences declare themselves within three years, making this the critical surveillance window.
This retrospective series from the Istituto Rizzoli reviews 280 patients with giant-cell tumor of bone followed for up to 44 years, asking which factors — radiographic grade, surgical margin, or adjuvant therapy — determine local recurrence, malignant transformation, and metastasis.
Surgical approach is the primary determinant of recurrence risk in GCT - wide excision eliminates recurrence but intralesional curettage carries significant risk. Most recurrences declare themselves within three years, making this the critical surveillance window.