Willert et al. examined periprosthetic tissues from 19 consecutive second-generation metal-on-metal hip revisions to determine whether immunological hypersensitivity could explain persistent pain, effusion, and osteolysis. Three control groups from non-metal-on-metal revisions were examined for comparison. The study defined the histological signature of ALVAL/LYDIA and tested whether bearing surface choice at revision determines symptom resolution.
Willert et al. examined periprosthetic tissues from 19 consecutive second-generation metal-on-metal hip revisions to determine whether immunological hypersensitivity could explain persistent pain, effusion, and osteolysis. Three control groups from non-metal-on-metal revisions were examined for comparison. The study defined the histological signature of ALVAL/LYDIA and tested whether bearing surface choice at revision determines symptom resolution.