Prospective database study from a Level I trauma center testing whether adequate resuscitation before reamed femoral nailing — rather than routine DCO — keeps ARDS rates low in polytrauma. 227 patients with ISS >17 and femoral shaft fractures were analyzed over 3 years. DCO was used in only 12% of patients; the rest underwent primary reamed nailing after lactate normalization.
The debate over femoral fracture management in polytrauma had long focused on the wrong variable: early nailing versus DCO. European centers using DCO in up to 47% of patients still reported ARDS rates above 26%, suggesting procedural choice alone was not the answer.
This paper reframes the decision around physiology, not timing. When you have a polytrauma patient with a femoral shaft fracture, proceed with reamed nailing once lactate is trending toward 2.5 mmol/L with stable hemodynamics and ventilation — even if that takes 14 hours.
Reserve DCO for patients who cannot clear their lactate despite aggressive resuscitation, or those with labile intracranial pressure.
Pape, the author of the European series this paper directly challenges, provided the editorial response and acknowledged that patient selection differences. Including the North American practice of having general surgeons clear patients for orthopedic procedures before they are included in studies. Likely explain much of the transatlantic ARDS rate discrepancy. Knowing this nuance matters when you encounter conflicting literature on this topic.
Resuscitation before Stabilization of Femoral Fractures Limits Acute Respiratory Distress Syndrome in Patients with Multiple Traumatic Injuries Despite Low Use of Damage Control Orthopedics.
Radiological Assessment of Osteo-Arthrosis.
Mesenchymal Stem Cells.
Traumatic Arthritis of the Hip after Dislocation and Acetabular Fractures: Treatment by Mold Arthroplasty. an End-Result Study Using a New Method of Result Evaluation.
Bone: Formation by Autoinduction.
Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation.
Interrater Reliability of a Modified Ashworth Scale of Muscle Spasticity
Osteoclast Differentiation Factor Is a Ligand for Osteoprotegerin/osteoclastogenesis-Inhibitory Factor and Is Identical to Trance/rankl.
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis. Vigor Study Group.
Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration.
Novel Regulators of Bone Formation: Molecular Clones and Activities.
The Diagnosis of Osteoporosis.
"modes of Failure" of Cemented Stem-Type Femoral Components: a Radiographic Analysis of Loosening.
Biomechanical Measures of Neuromuscular Control and Valgus Loading of the Knee Predict Anterior Cruciate Ligament Injury Risk in Female Athletes: a Prospective Study.
Femoroacetabular Impingement: a Cause for Osteoarthritis of the Hip.
Prevention of Infection in the Treatment of One Thousand and Twenty-Five Open Fractures of Long Bones: Retrospective and Prospective Analyses.
The Variation in Isometric Tension with Sarcomere Length in Vertebrate Muscle Fibres.
Osteoarthritis: a Disease of the Joint as an Organ.
Radiological Demarcation of Cemented Sockets in Total Hip Replacement.
Ectopic Ossification Following Total Hip Replacement. Incidence and a Method of Classification.
The Operation of the Century: Total Hip Replacement.
Fatty Muscle Degeneration in Cuff Ruptures. Pre- and Postoperative Evaluation by CT Scan.
Osseointegrated Titanium Implants. Requirements for Ensuring a Long-Lasting, Direct Bone-To-Implant Anchorage in Man.
The Etiology of Chondromalacia Patellae.
Fracture and Dislocation Classification Compendium-2018.
The Three Column Spine and Its Significance in the Classification of Acute Thoracolumbar Spinal Injuries.
Dislocations after Total Hip-Replacement Arthroplasties.
Patient Satisfaction after Total Knee Arthroplasty: Who Is Satisfied and Who Is Not?
Problems in the Management of Type III (severe) Open Fractures: a New Classification of Type III Open Fractures.
The Value of Postural Reduction in the Initial Management of Closed Injuries of the Spine with Paraplegia and Tetraplegia. I.
Vacuum-Assisted Closure: a New Method for Wound Control and Treatment: Animal Studies and Basic Foundation.
A System for the Functional Evaluation of Reconstructive Procedures after Surgical Treatment of Tumors of the Musculoskeletal System.
A Controlled Trial of Arthroscopic Surgery for Osteoarthritis of the Knee
The Stabilizing System of the Spine. Part I. Function, Dysfunction, Adaptation, and Enhancement.
The Outcome and Repair Integrity of Completely Arthroscopically Repaired Large and Massive Rotator Cuff Tears.
The Tension-Stress Effect on the Genesis and Growth of Tissues. Part I. the Influence of Stability of Fixation and Soft-Tissue Preservation.
A System for the Surgical Staging of Musculoskeletal Sarcoma.
A Comprehensive Classification of Thoracic and Lumbar Injuries
Effect of the Tyrosine Kinase Inhibitor Sti571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor
Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture.
Factors of Patellar Instability: an Anatomic Radiographic Study.
Displaced Proximal Humeral Fractures. I. Classification and Evaluation.
Hip Morphology Influences the Pattern of Damage to the Acetabular Cartilage: Femoroacetabular Impingement as a Cause of Early Osteoarthritis of the Hip.
Porosity of 3D Biomaterial Scaffolds and Osteogenesis.
A Report: the Definition and Classification of Cerebral Palsy April 2006.
Clinician's Guide to Prevention and Treatment of Osteoporosis.
Prevention of Venous Thromboembolism
The Development of Assessment of Spondyloarthritis International Society Classification Criteria for Axial Spondyloarthritis (part II): Validation and Final Selection
Radiation Exposure from CT Scans in Childhood and Subsequent Risk of Leukaemia and Brain Tumours: a Retrospective Cohort Study.
Epidemiology of Adult Fractures: a Review.
Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017.
Osteoblastic Cells Regulate the Haematopoietic Stem Cell Niche.
A Joint Coordinate System for the Clinical Description of Three-Dimensional Motions: Application to the Knee.
Consensus Statement on Concussion in Sport-The 5th International Conference on Concussion in Sport Held in Berlin, October 2016.
Oarsi Guidelines for the Non-Surgical Management of Knee Osteoarthritis.
Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050.
Metastasis to Bone: Causes, Consequences and Therapeutic Opportunities.
Role of Proinflammatory Cytokines in the Pathophysiology of Osteoarthritis.
The Basic Science of Articular Cartilage: Structure, Composition, and Function.
Osteoporosis: Now and the Future.
Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity.
Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs. a 1:1:2 Ratio and Mortality in Patients with Severe Trauma: the Proppr Randomized Clinical Trial
Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression Caused by Metastatic Cancer: a Randomised Trial.
Fracture and Dislocation Classification Compendium - 2007: Orthopaedic Trauma Association Classification, Database and Outcomes Committee.
Peek Biomaterials in Trauma, Orthopedic, and Spinal Implants.
Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older
The Long-Term Consequence of Anterior Cruciate Ligament and Meniscus Injuries: Osteoarthritis.
Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America.
The Amazing Osteocyte.
Osteosarcoma Incidence and Survival Rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program.
Projected Volume of Primary Total Joint Arthroplasty in the U.s., 2014 to 2030.
The 2018 Definition of Periprosthetic Hip and Knee Infection: an Evidence-Based and Validated Criteria.
Bone Quality--The Material and Structural Basis of Bone Strength and Fragility.
Prevalence of Muscular Dystrophies: a Systematic Literature Review.
Mechanisms of Bone Metastasis.
The Compressive Behavior of Bone as a Two-Phase Porous Structure.
Metastatic Bone Disease: Clinical Features, Pathophysiology and Treatment Strategies.
Diagnosis and Treatment of Hip and Knee Osteoarthritis
Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis.
Opgl Is a Key Regulator of Osteoclastogenesis, Lymphocyte Development and Lymph-Node Organogenesis.
Osteoarthritis: New Insights. Part 1: the Disease and Its Risk Factors.
Morbidity at Bone Graft Donor Sites.
Articular Cartilage Repair: Basic Science and Clinical Progress. a Review of the Current Status and Prospects.
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.
Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures
Assessment of Coma and Impaired Consciousness. a Practical Scale.
Development and Reliability of a System to Classify Gross Motor Function in Children with Cerebral Palsy
Validation Study of Womac: a Health Status Instrument for Measuring Clinically Important Patient Relevant Outcomes to Antirheumatic Drug Therapy in Patients with Osteoarthritis of the Hip or Knee.
Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030.
The Oswestry Disability Index.
A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population.
A Clinical Method of Functional Assessment of the Shoulder.
Rating Systems in the Evaluation of Knee Ligament Injuries.
Sf-36 Health Survey Update
Rationale of the Knee Society Clinical Rating System.
Knee Injury and Osteoarthritis Outcome Score (koos)--Development of a Self-Administered Outcome Measure.
Evaluation of Knee Ligament Surgery Results with Special Emphasis on Use of a Scoring Scale.
Development and Validation of the International Knee Documentation Committee Subjective Knee Form.
Delirium in Older Persons.Citation only
Calcium Phosphate Ceramics as Hard Tissue Prosthetics.
The Knee Society Total Knee Arthroplasty Roentgenographic Evaluation and Scoring System.
Prospective database study from a Level I trauma center testing whether adequate resuscitation before reamed femoral nailing — rather than routine DCO — keeps ARDS rates low in polytrauma. 227 patients with ISS >17 and femoral shaft fractures were analyzed over 3 years. DCO was used in only 12% of patients; the rest underwent primary reamed nailing after lactate normalization.
The debate over femoral fracture management in polytrauma had long focused on the wrong variable: early nailing versus DCO. European centers using DCO in up to 47% of patients still reported ARDS rates above 26%, suggesting procedural choice alone was not the answer.
This paper reframes the decision around physiology, not timing. When you have a polytrauma patient with a femoral shaft fracture, proceed with reamed nailing once lactate is trending toward 2.5 mmol/L with stable hemodynamics and ventilation — even if that takes 14 hours.
Reserve DCO for patients who cannot clear their lactate despite aggressive resuscitation, or those with labile intracranial pressure.
Pape, the author of the European series this paper directly challenges, provided the editorial response and acknowledged that patient selection differences. Including the North American practice of having general surgeons clear patients for orthopedic procedures before they are included in studies. Likely explain much of the transatlantic ARDS rate discrepancy. Knowing this nuance matters when you encounter conflicting literature on this topic.