Urist tested whether devitalized, decalcified bone matrix implanted in extraskeletal sites induces new bone formation from host cells alone. Experimental animal study: roughly 70 experiments in about 300 animals with intramuscular implants of decalcified bone, followed histologically through the cellular sequence of matrix resorption and new-bone formation.
Urist tested whether devitalized, decalcified bone matrix implanted in extraskeletal sites induces new bone formation from host cells alone. Experimental animal study: roughly 70 experiments in about 300 animals with intramuscular implants of decalcified bone, followed histologically through the cellular sequence of matrix resorption and new-bone formation.