This 2001 narrative review by Sekhon and Fehlings synthesizes population-level data on the incidence, demographics, injury patterns, and economic burden of acute SCI, then surveys the pathophysiology of primary and secondary injury mechanisms — from vascular ischemia and ionic derangements to free radical cascades and oligodendrocyte apoptosis.
This 2001 narrative review by Sekhon and Fehlings synthesizes population-level data on the incidence, demographics, injury patterns, and economic burden of acute SCI, then surveys the pathophysiology of primary and secondary injury mechanisms — from vascular ischemia and ionic derangements to free radical cascades and oligodendrocyte apoptosis.