Bosse tested whether reconstruction or amputation determines functional outcome after severe, limb-threatening lower-extremity injury. Multicenter prospective observational study at eight Level I trauma centers (enrolled 1994 to 1997; 569 patients, 545 analyzed), comparing amputation with reconstruction; primary outcome was the Sickness Impact Profile (SIP) at two years.
Bosse tested whether reconstruction or amputation determines functional outcome after severe, limb-threatening lower-extremity injury. Multicenter prospective observational study at eight Level I trauma centers (enrolled 1994 to 1997; 569 patients, 545 analyzed), comparing amputation with reconstruction; primary outcome was the Sickness Impact Profile (SIP) at two years.